Poor nutrition for pregnant women may lead to their child being diabetic – A study

Poor nutrition for pregnant women may lead to their child being diabetic – A study

In a study conducted over rats, it has been discovered that poor nutrition in uterus can cause a person at greater risk of developing type 2 diabetes and other age-related diseases later in life. This finding could lead to new ways to find people who have
a higher than normal risk of developing these diseases and perhaps may make it possible to identify "white" to those who direct strategic treatments.

The Research has been conducted by a team of specialists from the University of Cambridge and Toxicology Unit, Medical Research Council at the University of Leicester, both universities in the UK. Research shows that, in rats and humans, the body of individuals
subjected in uterus to a diet with certain shortcomings, it is less able to store fats properly in later life.

Storing fat in the right areas of the body is important, because otherwise they can accumulate in places like the liver and muscles where it is more likely to cause illness. One way in which our body copes with a diet modern Western fat is to store excess
calories in fat cells. When these cells are not able to absorb more fat, then they are placed elsewhere, such as the liver, where they are much more dangerous and can cause diabetes.

The team of researchers Anne Willis (Leicester University) and Susan Ozanne (Cambridge University) found that this process is controlled by a substance called miR-483-3p. It was further found that the miR-483-3p was produced in higher levels in individuals
who had experienced the effects of poor diet in the womb of their mothers, than those who were better fed during the intrauterine period.

When fed to rats pregnant women with low protein diets, their offspring had higher levels of miR-483-3p. This led to develop fat cells were smaller and less able to properly store fat in adulthood. These rats had an increased risk of developing diabetes
when they are fed diets rich in calories.

It is known that rats are a good model to study human diseases associated with diet, and the team has also tested and the presence of high levels miR-483-3p in a group of people who had a low birth weight.

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Posted by Fouad Ashraf on Feb 17 2012. Filed under Sci-Tech. You can follow any responses to this entry through the RSS 2.0. You can leave a response or trackback to this entry